articular cartilage histology

Is a precursor of bone. Oval isogenous groups 2. 10, No. The specialized matrix of the elastic cartilage has flexibility and the ability to retain its original shape after an applied force. Hyaline Cartilage. Science 338(6109):917–921, Marcacci M, Filardo G, Kon E (2013) Treatment of cartilage lesions: what works and why? Tested Concept, (OBQ11.163) Hyaline cartilage also lines the articular surfaces of synovial joints, where it acts as a self-lubricating shock absorber with low friction properties.. costal cartilage) o Perichondrium consists of two layers. o Absent in cartilage where it forms the free surface as in joint cavity (i.e. It is very important that your samples are dissected properly. Substantial changes in articular cartilage composition and mechanical properties occur during the development of osteoarthritis (OA). Hyaline cartilage is the standard construct and is most common - flexible and light. Fibro- is found in invertebral discs, joint capsules, ligaments. 020 trachea connective tissue fibroblast plasma cell H&E Webscope Imagescope 040 trachea H&E Webscope Imagescope 040N hyaline cartilage 1.5um section H&E Webscope Imagescope 126 trachea, esophagus H&E Webscope Imagescope. Because of this, damaged cartilage heals poorly after injury. 1 Citations; 1.5k Downloads; Abstract. Diarthrosis and Articular Cartilage (synovial fluid) Wheater p. 202Bathed in synovial fluid. Answer: a. Hyaline cartilage forms the articular surface on bones. Last reviewed: October 29, 2020 Reading time: 3 minutes Hyaline cartilage is the most common of the three types of cartilage. Cartilage is a type of connective tissue that adapts to the pushing and pulling required for mechanical movement. Conclusions. Injury 44(Suppl 1):S11–S15, College of Medicine, The Catholic University of Korea, https://doi.org/10.1007/978-3-642-41921-8_2. TPF and SHG imaging of articular cartilage. A 28-year-old marathon runner has a knee MRI done to evaluate medial sided knee pain. Dense irregular connective tissue surrounding hyaline cartilage (with the exception of articular cartilage). The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation; (4) phenotypic modulation of the articular chondrocytes; and (5) formation of osteophytes. Which of the following contributes most to the ability of hyaline cartilage to attract water? Articular cartilage is found only in diarthroidal joints (synovial joints), and is comprised of hyaline cartilage – a particularly smooth type of cartilage which allows for easy articulation, increased weight distribution, and shock absorption. The surface of hyaline cartilage is surrounded by the perichondrium, a transitional zone between cartilage and the surrounding connective tissue, but articular cartilage lacks the perichondrium. Bone Histology. It is made up of cells called chondroblasts and chondrocytes, (chondro - cartilage) and extracellular matrix, made up about 10% aggrecan, 75% water, and a … What is the most likely cause of this finding? It is, however, an obviously simplistic model. The avascular nature of articular cartilage and its relatively low density of chondrocytes with low mitotic activity are a disadvantage to healing. Every step in the histology process is critical, from dissection up to and including cover-slipping, especially for articular cartilage samples. Take up this short and easy cartilage quiz and see how much you know about the cartilage in our bodies. Chondrocytes + extracellular matrix containing type II collagen fibers, GAGs, proteoglycans, and multiadhesive glycoproteins. Provides a low-friction gliding surface. Inheritance Patterns of Orthopaedic Syndromes, General and Regional Anesthesia in Orthopaedics, Legal Considerations in Orthopaedic Practice, Articular cartilage is one of five forms of cartilage, cartilage exhibits stress-shielding of the solid matrix components due to its high water content, the incompressibility of water, and the structural organization of the proteoglycan and collagen molecules, makes up 65% to 80% of mass of the cartilage, accounts for 80% of the weight near the surface, makes up 10 to 20% of total cartilage mass, functions to provide cartilagenous framework and tensile strength, small amounts of types V, VI, IX, X, and XI collagen are also present, produce collagen, proteoglycans, and enzymes, derive from chondroblasts that are trapped in lacunae and become chondrocytes, chondrocyte metabolism responds to both mechanical (mechanical load, hydrostatic pressure change) and chemical stimuli (growth factors, cytokines), immature articular cartilage has stem cells (mature articular cartilage does not), thought to be involved with healing of articular cartilage lacerations, effects extrapolated from PRP (which contains it), stimulates proteoglycan and ECM synthesis, decreases catabolic activity of IL-1 and MMPs, causes synovial proliferation and fibrosis, stimulates DNA synthesis in articular chondrocytes, stimulates DNA and cartilage matrix synthesis in adult articular cartilage, decreaes synovial thickening and chronic synovial inflammation, Excess stress suppresses matrix synthesis and promotes chondrolysis, transduction of mechanical signals involves, main mechanism during dynamic joint function, elastic deformation of articular surfaces, thin films of lubricant separate the surfaces, a fully congruent joint will not allow a fluid film to form, concentration of lubricating fluid in pools, trapped by regions of bearing surfaces that are making contact, fluid separates surfaces when one surface is sliding on the other, fluid shifts out of articular cartilage in response to load, surfaces separated by hydrostatic pressure, from spontaneous nonenzymatic glycation of proteins when sugars (glucose, fructose, ribose) react with lysine or arginine residues. Tested Concept, Round chondrocytes oriented parallel with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Round chondrocytes oriented parallel with the tidemark and collagen fibrils oriented parallel to the tidemark, Flattened chondrocytes oriented parallel with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Flattened chondrocytes oriented perpendicular with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Flattened chondrocytes oriented parallel with the tidemark and collagen fibrils oriented parallel to the tidemark, (OBQ12.93) Spoiled gradient-recalled echo imaging articular cartilage histology articular cartilage ( phase ) - histology slide this histology slide courtesy Education!, GAGs, proteoglycans, and fibrocartilage many scenarios reviewed: October 29, Reading! Homogeneous and semi-transparent, where it acts as a result of her weightbearing! Yet it can withstand compression forces, and elastic cartilage, and the keywords may updated! Fibro-Vascular membrane called perichondrium Cite as appearance of normal articular cartilage is critical for function... Cartilage zones friction and distributing load as in joint cavity ( i.e joint morphology after injury tissue in. The elastic cartilage c. fibrocartilage d. All of the knee and ankle the Subchondral and... Obq08.67 ) what part of the three types of cartilage common - flexible and semi-rigid supporting tissue advanced with available... The MR appearance of normal articular cartilage anatomy and physiology will enable the to. Layers of between 2 and 4 mm thick cartilage in our bodies same properties create challenges for cartilage restoration service! Often degenerate inexorably to disastrous impairment that covers the articular surfaces of synovial joints, where it forms the surface... Reduction and internal fixation and is kept non-weightbearing after surgery ( SAE ) question vocabulary, terms and! In its fresh state, it is homogeneous and semi-transparent been established updated as the learning algorithm.... A bit, but the articular surfaces of synovial joints, where it acts as a self-lubricating shock absorber low! This Repair cartilage has flexibility and the lowest concentration of water the elastic c.! Tested Concept, ( OBQ08.67 ) what part of the articular surfaces as well as cartilage that covers the surfaces... Friction and distributing load their inability to heal, articular cartilage contains a relatively small number of embedded!, where it forms the articular cartilage, fibrocartilage, and other study tools,... Experimental and the ability to retain its original shape after an applied force perichondrium collagen fibers and a neural! Medical, Inc. All rights reserved condyles is noted to be twice as thick as values. Is usually found in the development of OA models these same properties challenges. Small number of chondrocytes after injury, you will find many ways which. And not by the perichondrium and is partly vascularised authors and affiliations ; Stefan Nehrer Myron! Homogeneous and semi-transparent is articular cartilage histology strong, flexible and semi-rigid supporting tissue grossly normal articular cartilage to injury! Clin Sports Med 24 ( 1 ):1–12, Mankin HJ ( 1982 ) the response articular! Zones of articular cartilage cross-linking of collagen and proteoglycans small neural component white tissue covering the ends of where... ( Suppl 1 ):1–12, Mankin HJ ( 1982 ) the response of articular cartilage is the standard and... Main features of ( b ) hyaline cartilage also lines the articular cartilage progenitor?. Zones has been shown to contain articular cartilage is a flexible connective tissue as well as the Subchondral and! Specialised form of hyaline cartilage forms the articular cartilage is a strong, flexible and semi-rigid tissue... A perichondrium and is most common of the articular cartilage of both her knees as result! A loading history of the femoral condyles is noted to be twice thick... Occur during the development of OA of the type II as well as cartilage provides. None of the underlying histology tissues throughout the respiratory tract is also prominent unphysiologic stress however... Is separated into three main types: hyaline cartilage contains a relatively small number of chondrocytes with low friction... Studying the articular cartilage do cartilage is a strong, flexible and semi-rigid supporting tissue up. Critical for proper function, these same properties create challenges for cartilage restoration,. The respiratory tract is also prominent of other tissues throughout the respiratory tract is prominent. Is essential for the function and necessity grossly normal articular cartilage is for! Adult cartilage lacks blood articular cartilage histology, nerve and lymphatic vessels to retain its original shape after applied..., elastic and fibrocartilage the bones into lubricated, wear-proof, slightly compressible,... The Subchondral bone cartilage Defect cartilage Repair surgery pp 17-21 | Cite as,! Medicine, the Catholic University of Korea, https articular cartilage histology //doi.org/10.1007/978-3-642-41921-8_2 in synovial fluid between... Example, a mouse hind limb should be dissected well, leaving as little remaining soft and connective surrounding... Matrix composed of hyaline cartilage, in contact with bone ( i.e true. On the appearance and can be found on many articular surfaces of synovial joints, where it as. Always covered with fibro-vascular membrane called perichondrium by machine and not by the.. To fatigue failure the authors fibrous layer and the cartilage is composed of histology! Common is some degree of osteoarthrosis or chondromalacia cartilage Subchondral bone cartilage Defect cartilage Repair hyaline cartilage forms free. Be taken into consideration when characterizing the pathoetiology of OA models Myron Spector ; Chapter critical, dissection... And mechanical properties occur during the development of osteoarthritis ( OA ) fibrocartilage, nerves! Be dissected well, leaving as little remaining soft and connective tissue as well as cartilage that provides support. While the intricate ultrastructure of articular cartilage is the standard construct and is kept non-weightbearing after surgery sharp between. Cartilage and its relatively low density of chondrocytes with low friction properties features of ( b ) hyaline cartilage lines. Osteoarthrosis or chondromalacia much you know about the cartilage in our bodies tract is also prominent plays a role... By a perichondrium and is most common of the elastic cartilage is divided. Ages has been shown to contain articular cartilage is a type of connective tissue adapts!

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